Cannabis Sativa L.

1 Item

Potent inhibition of human cytochrome P450 by cannabidiol

In this study, we examined the inhibitory effects of Δ9-tetrahydrocannabinol (Δ9-THC), cannabidiol (CBD), and cannabinol (CBN), the three major cannabinoids, on the activity of human cytochrome P450 (CYP) 3A enzymes. Furthermore, we investigated the kinetics and structural requirement for the inhibitory effect of CBD on the CYP3A activity. Main methods: Diltiazem N-demethylase activity of recombinant […]